Dose- and Time-Related Effects of Pilocarpine Mouthwash on Salivation
송제일, 박조은, 김혜경, 김미은, 김기석,
소속 상세정보
송제일 ( Song Je-Il ) - Dankook University College of Dentistry Department of Oral Medicine
박조은 ( Park Jo-Eun ) - Dankook University College of Dentistry Department of Oral Medicine
김혜경 ( Kim Hye-Kyoung ) - Dankook University College of Dentistry Department of Oral Medicine
김미은 ( Kim Mee-Eun ) - Dankook University College of Dentistry Department of Oral Medicine
김기석 ( Kim Ki-Suk ) - Dankook University College of Dentistry Department of Oral Medicine
Abstract
Purpose: Pilocarpine as a salivation stimulant in pill form has mostly been used to relieve oral dryness for xerostomic patients but its use may often be limited due to variable side effects from systemic absorption. Therefore, the purpose of this study was to investigate the effects of pilocarpine mouthwash on salivation according to the variable concentration and duration for healthy volunteers. Related adverse effects and subjective assessment on its effects on salivation were also examined.
Methods: This study was performed as placebo-controlled, double-blind, randomized clinical trial. Thirty healthy volunteers (male=23, mean age=22.2 years) were randomly allocated to 6 groups with the different concentration of pilocarpine mouthwash (placebo, 0.1%, 0.5%, 1.0%, 1.5%, and 2.0%). The whole experiment consisted of 3 sessions according to the duration of mouthwash, i.e., 1, 3, and 5 minutes with the mean wash-out period ≥2 days between the sessions. Unstimulated whole saliva was collected before and after gargling with a mouthwash.
Results: Salivation of the higher concentration groups ≥1% significantly increased than those of lower concentration group.
The application period of mouthwash did not cause any changes of salivary flow rate at the higher concentrations ≥1.0%. The lower concentrations of 0.5% and 0.1% had no effects on salivation even after 5-minute mouthwash. There was no significant difference between blood pressure and pulse rate before and after use of mouthwash.
Conclusions: From the results of the current study, pilocarpine mouthwash with at least 1.0% concentration more than a minute might be clinically effective in salivation without any serious side effects. Dose of mouthwash rather than duration seems to be a critical factor to salivation.
키워드
Dose; Mouthwash; Pilocarpine; Salivation; Time; Topical
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